KMID : 0613820180280010110
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Journal of Life Science 2018 Volume.28 No. 1 p.110 ~ p.115
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Effects of Methanol Extracts from Diospyros malabarica Stems on Growth and Biofilm Formation of Oral Bacteria
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Kim Hye-Soo
Kwon Hyun-Sook Kim Chul-Hwan Lee Sang-Woo Kongmany Sydara Cho Soo-Jeong
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Abstract
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This study was conducted to investigate the potential of medicinal plants as oral health materials derived from natural products. Among the extracts from 200 medicinal plants grown in Nepal, Laos, Mongolia, Bangladesh, Vietnam, and China, stem extracts from Diospyros malabarica (1 mg/disc) showed the highest antibacterial activity against Porphyromonas gingivalis ATCC33277 and Streptococcus mutans ATCC25175. The D. malabarica stem extracts showed antibacterial activity similar to chlorhexidine, sodium lauryl sulfate, and triclosan, which were used as a positive control, as well as higher antibacterial activity against S. mutans ATCC25175 than P. gingivalis ATCC33277. The D. malabarica stem extracts showed bactericidal action (MBC, 0.4 mg/ml) against P. gingivalis ATCC33277 and bacteriostatic action against S. mutans ATCC25175. The biofilm production rate of S. mutans ATCC25175 and the expression of the comX gene associated to biofilm formation in the cultures treated with 0.2-1.0 mg/ml of D. malabarica stem extracts were suppressed in a concentration-dependent manner. Based on the above results, it can be concluded that D. malabarica stem extracts can be used as oral health material derived from natural materials, as demonstrated by the bacteriostatic action and inhibition of biofilm formation against S. mutans ATCC25175.
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KEYWORD
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Biofilm formation, comX, Diospyros malabarica, P. gingivalis, S. mutans
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